Başka diğer ruhsal rahatsızlık durumlarında da olduğu gibi panik atağın da kesin nedeni henüz bilinmemektedir. Bununla birlikte, söz konusu atakların yaşanan travmatik veya aşırı stresli bir dönem ya da beyindeki nörotransmiter hareketliliğindeki dengesizlik ve benzeri ile ilişkili olduğu düşünülmektedir.
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